Atlas of Clinical Hematology(6th Edition)

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[原版书籍]Atlas of Clinical Hematology(6th Edition)



Here's a copy of the table of contents from Downloaded PDF:

Contents
Methodology
I Techniques of Specimen Collection and Preparation 3
Blood Smear 4
Bone Marrow 4
Fine-Needle Aspiration of Lymph Nodes and Tumors 5
Splenic Aspiration 6
Concentrating Leukocytes from Peripheral Blood in Leukocytopenia 6
Demonstration of Sickle Cells 6
II Light Microscopic Procedures 7
1 Staining Methods for the Morphologic and Cytochemical
Differentiation of Cells 8
1.1 Pappenheim’s Stain (Panoptic Stain) 8
1.2 Undritz Toluidine Blue Stain for Basophils 8
1.3 Mayer’s Acid Hemalum Nuclear Stain 8
1.4 Heilmeyer’s Reticulocyte Stain 8
1.5 Heinz Body Test of Beutler 8
1.6 Nile Blue Sulfate Stain 9
1.7 Kleihauer-Betke Stain for Demonstrating Fetal Hemoglobin
in Red Blood Cells 9
1.8 Kleihauer-Betke Stain for Demonstrating Methemoglobin-
Containing Cells in Blood Smears 10
1.9 Berlin Blue Iron Stain 10
1.10 Cytochemical Determination of Glycogen in Blood Cells
by the Periodic Acid Schiff Reaction and Diastase Test
(PAS Reaction) 11
1.11 Sudan Black B Stain 13
1.12 Cytochemical Determination of Peroxidase 13
1.13 Hydrolases 13
1.14 Appendix 16


2 Immunocytochemical Detection of Cell-Surface and Intracellular
Antigens 18
3 Staining Methods for the Detection of Blood Parasites 19
3.1 “Thick Smear” Method 19
3.2 Bartonellosis 19
3.3 Detection of Blood Parasites in Bone Marrow Smears 19
3.4 Toxoplasmosis 19
3.5 Microfiliariasis 19
3.6 Mycobacterium Species (M. tuberculosis, M. leprae)19
Illustrations
III Overview of Cells in the Blood, Bone Marrow,
and Lymph Nodes 23
IV Blood and Bone Marrow 27
4 Individual Cells 28
4.1 Light Microscopic Morphology and Cytochemistry 28
5 Bone Marrow 67
5.1 Composition of Normal Bone Marrow 69
5.2 Disturbances of Erythropoiesis 80
5.3 Reactive Blood and Bone Marrow Changes 107
5.4 Bone Marrow Aplasias (Panmyelopathies) 118
5.5 Storage Diseases 122
5.6 Hemophagocytic Syndromes 129
5.7 Histiocytosis X 132
5.8 Chronic Myeloproliferative Disorders (CMPD) 134
5.9 Myelodysplastic Syndromes (MDS) 158
5.10 Acute Leukemias 170
5.11 Neoplasias of Tissue Mast Cells (Malignant Mastocytoses) 286
V Lymph Nodes and Spleen 293
6. Cytology of Lymph Node and Splenic Aspirates 294
6.1 Reactive Lymph Node Hyperplasia 295
6.2 Infectious Mononucleosis 304
6.3 Persistent Polyclonal B Lymphocytosis 307
6.4 Malignant Non-Hodgkin Lymphomas
and Hodgkin Lymphoma 308


VI Tumor Aspirates from Bone Marrow Involved
by Metastatic Disease 385
VII Blood Parasites and Other Principal Causative Organisms
of Tropical Diseases 399
7 Blood Parasites 400
7.1 Malaria 400
7.2 African Trypanosomiasis (Sleeping Sickness) 410
7.3 American Trypanosomiasis (Chagas Disease) 411
7.4 Kala Azar or Visceral Leishmaniasis 414
7.5 Cutaneous Leishmaniasis (Oriental Sore) 416
7.6 Toxoplasmosis 416
7.7 Loa Loa 417
7.8 Wuchereria bancrofti and Brugia malayi 417
7.9 Mansonella (Dipetalonema) Perstans 420
8 Further Important Causative Organisms
of Tropical Diseases 421
8.1 Relapsing Fever 421
8.2 Bartonellosis (Oroya Fever) 421
8.3 Leprosy 423
Subject Index 425



Here's a copy of the the Preface:

Preface to the Sixth Edition
Soon after the 5th edition of this volume appeared, the WHO published de-tails on the pathology and genetics of the hematopoietic and lymphatic tis-sues. Work in progress found in short journal articles had already been in-tegrated into the last edition. Now it was possible to incorporate the new proposals for classification and diagnosis and to include figures of newtypes
of leukemia and lymphoma. These include leukemias of dendritic cells, in- travascular large B-cell lymphoma, the liver-spleen T-cell lymphoma as well as persistent polyclonal B-cell lymphocytosis, which is placed between be-nign and malignant.
The present volume completes and extends the cytogenetic and molecu-lar-genetic characterization of the different diseases and incorporates new figures. At this point we would like to thank PD Dr. Claudia Schoch ,Munich,for her valuable help and for graciously providing new zytogenetic and FISH figures. In addition, several figures and tables were replaced, and a schematic drawing of the topography of lymphoma infiltrationin bone marrow (cour-tesy of Prof. Dr. H.E. Schaefer, Freiburg) was added to the lymphoma chap-ter.
Even in 2004, diagnosis in hematology and lymphomas starts, as a rule, with the morphological examination of blood, bone marrow or lymphatic tissues. It can direct the subsequent use of immunophenotyping, cytoge-netics and molecular genetics, in this way demonstrating ways of saving money and avoiding unnecessary investigations.
Gene expression profiling and, in the future, proteomics still represent very expensive methods that must find their place in diagnosis and prognos-tic evaluation.Gene profiling studies have already confirmed morphological subtypes in AML, e.g., M3 and M3V, which cannot be distinguished into strictly separate groups by cytogenetic and molecular-genetic methods.
New therapeutic measures (especially immunotherapy) have brought inter-esting progress into the MDS group. For example, the biological entity 5q minus syndrome,which is well defined by morphology and cytogenetics, re-sponds very well to treatment with the thalidomide derivative CC 5013. The fusion gene BCR-ABL, which was originally detected by cytogenesis and is today routinely detected by FISH or PCR in CML, was the first example of a specifically tailored molecular therapy in a tumor; certainly other examples will follow. Cases of ALL involving t(9;22), t(4;11) and t(8;14) have also been established as separate prognostic groups with special therapeutic problems.
All of these examples demonstrate that a comprehensive arsenal of diag- nostic method shas to be used today for diagnostic and prognostic decisions and individualized therapeutic planning.
We are again grateful to Prof. Dr. R. Disko of Munich who agreed to revise and update the chapter on the principal causative agents of tropical diseases. Finally we wish to thank Mrs. Stephanie Benko and the entire staff of Spring-er-Verlag in Heidelberg as well as Ms. Marina Litterer at ProEdit GmbH for their thoughtful and effective support.



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