Biological Feedback: Rene Thomas, Richard D'Ari

Description

Clearly explaining the logical analysis of biological control phenomena, Biological Feedback answers questions concerning everything from regulation to logic. This rare monograph presents a formal methodology for analyzing the dynamic behavior of complex systems. The easy-to-read text describes a simple logical formalization called "kinetic logic". The reader discovers how this method is used to predict all possible patterns of behavior of which a system is capable. It includes specific conditions required for each pattern. It also explains how to modify an incorrect model in order to account for the observed behavior. The authors give special attention to the two basic types of simple feedback loops: positive and negative. This volume is filled with easy-to-use tables, providing quick reference throughout the book. The subject matter is of great interest to everyone working in molecular genetics and developmental biology. Researchers, immunologists, physical chemists, physicists, electrical engineers, economists, and mathematicians will find this unique text to be an informative, indispensable resource.

TABLE OF CONTENTS
Prologue: Philosophy of the Book
Part I: Tools
Chapter 1
Introduction to Part I
Chapter 2
Elements of Combinatorial Logic
Chapter 3
Kinetic Logic I: From Logical Structure to Behavior
Chapter 4
Kinetic Logic II: The Conditions Determining the Choices Among Pathways
Chapter 5
Inductive Use of Kinetic Logic
Chapter 6
Elements of the Differential Description
Chapter 7
Generalized Kinetic Logic
Chapter 8
Generalized Logical vs. Differential Description
Part II: Feedback Loops
Chapter 9
Introduction to Part II
Chapter 10
Simple Negative Feedback Loops Generate Homeostasis: Differential Description
Chapter 11
Simple Negative Feedback Loops Generate Homeostasis: Logical Description
Chapter 12
Simple Positive Feedback Loops Generate Differentiation: Differential Description
Chapter 13
Simple Positive Feedback Loops Generate Multistationarity: Logical Description
Chapter 14
How Can a Transient Signal Switch a Function on Permanently?
Chapter 15
Many Steady States
Chapter 16
Systems with Positive and Negative Feedback Loops
Part III: Applications
Chapter 17
Epigenetic Differences and Multiple Steady States
Chapter 18
Logical Treatment of Diffusion
Chapter 19
The SOS Response
Chapter 20
Bacteriophage ?
Chapter 21
Neuronal Networks
Chapter 22
A Model Analysis of the Immune Response
Chapter 23
On Determination and Differentiation
Concluding Remarks
Appendix 1
How to Find a Steady State Value By Iteration
Appendix 2
Trajectories and Evolution
Appendix 3
A Little More about Linear Stability Analysis
Appendix 4
Asynchronous vs. Synchronous Description
Index

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