Biological Physics of the Developing Embryo

Description

"Biological Physics of the Developing Embryo" is a remarkable causal description of embryonic development as controlled by the interplay of physical and biomolecular processes. Based on their expertise in both theory and experiment (Forgacs is a condensed matter physicist and Newman was trained in physical chemistry, and each currently directs a program in cell and tissue biology), the authors present an engaging and original view of cell-cell interactions and multicellular morphogenesis and pattern formation. They offer a paradigm within which spatiotemporal cell behavior is explained by the concerted action of "generic" physical principles and specific genetic factors. Reading the book is made easy for both the physical and life scientist by the logic of its presentation: early development is presented according to the major stages familiar to the biologist in a clear fashion that also provides a short introduction to each event or process (cleavage, differentiation, gastrulation, segmentation, several kinds of organogenesis, fertilization) for the physicist. The physical modeling of each developmental episode is then discussed, making a smooth transition that is not overwhelming for the biologist. Each chapter ends with a short "perspective" which epitomizes the main conceptual lessons of the chapter resulting from the synthesis of experimental facts and relevant physical models. Books of this kind are rare, although badly needed, due to the large accumulation of facts. Not to be lost in the sea of data, an atheoretical descriptive analysis is no longer an option. Experimental results must be supplemented by systematic modeling for useful interpretations to emerge. The book by Forgacs and Newman teaches us how to accomplish this.




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