Cancer Chemoprevention: Volume 1&II

Description

Cancer Chemoprevention: Volume 1: Promising Cancer Chemopreventive Agents (Cancer Drug Discovery and Development)

Publisher: Humana Press
Number Of Pages: 680
Publication Date: 2004-06-04
Sales Rank: 2869953
ISBN / ASIN: 158829076X
EAN: 9781588290762
Binding: Hardcover
Manufacturer: Humana Press
Studio: Humana Press

Book Description:

A comprehensive reference survey on the identification and development of promising cancer chemopreventive agents that will help stimulate further novel research and new approvable drugs. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal read.freeduan.com transduction modulators, antioxidants, vitamins, and minerals. The overall focus is on molecular targets and mechanisms. A second volume, Strategies in Chemoprevention, describes the exciting methodologies that will accelerate progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs.

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Cancer Chemoprevention: Volume 2: Strategies for Cancer Chemoprevention (Cancer Drug Discovery and Development)

Publisher: Humana Press
Number Of Pages: 568
Publication Date: 2005-02-01
Sales Rank: 2190849
ISBN / ASIN: 1588290778
EAN: 9781588290779
Binding: Hardcover
Manufacturer: Humana Press
Studio: Humana Press

Book Description:

Leading researchers comprehensively describe the exciting methodologies that are accelerating progress in chemoprevention and review the state of clinical development of preventive agents in the major human cancer target organs. The authors provide sound guidelines for cancer chemopreventive drug development, detailing general strategies and methods for drug discovery, preclinical efficacy, characterization of precancers, safety evaluation of clinical cohorts, and clinical trial design. The emphasis is on documenting the characterization and application of reliable biomarkers during chemopreventive drug development. Highlights read.freeduan.com include an elegant approach to identifying chemopreventive agents in natural products, the development of preclinical models for evaluating potential chemopreventive agents, the genomics and proteomics of potential applications, and approaches for determining which populations will likely benefit from chemopreventive intervention. A companion volume, Promising Cancer Chemopreventive Agents, comprehensively surveys those agents that have promise, or have already been successfully used, to treat precancerous conditions or inhibit carcinogenesis.

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