Cell Biology of the Axon (Results and Problems in Cell Differentiation)

Description

Recent years have witnessed striking advances in research on axons at a cellular level that substantially impact our current understanding of axonal biology. Newer findings and their ramifications are critically reviewed in the 16 chapters of this volume by authors highly qualified by virtue of their scientific contributions to research areas they know and write about.

Five basic areas (I to V) germane to axonal biology are highlighted, beginning with (I) signaling interactions mediating myelination, and differentiation of axonal membrane domains; (IIa) issues surrounding organization and transport dynamics of neurofilaments in axons, (IIb) mechanisms regulating microtubule organization and dynamics, misregulation of which causes axonal degeneration, and (IIc) the roles actin binding proteins play in regulating organization and functions of the actin filament system in mature and growing axons; (IIIa) myosin motor proteins and cargoes intrinsic to the axon compartment, (IIIb) mitochondrial transport motors, and imperatives governing transport dynamics and directional delivery, (IIIc) mechanisms mediating retrograde signaling associated with NGF’s role in trophic-dependent neuronal survival, and (IIId) potential for impaired subcellular targeting of a -synuclein as a mechanism for accumulation of Lewy body inclusions in synucleinopathies; (IVa) occurrence and organization of discrete ribosome-containing domains in axons, (IVb) endogenous mRNAs, classes of proteins translated locally, and RNP trafficking in axons, (IVc) importance of locally synthesized nuclear encoded mitochondrial proteins for maintenance, function and survival of axons, (IVd) occurrence of RNA trafficking from glial cells to axons, and significance glial RNA transcripts may play in expression in axons and axon terminals, (IVe) RNA trafficking and localization of RNA transcripts in axonal growth cones, and signaling pathways that modulate local protein synthesis for directional elongation, and (IVf) genetic and molecular defects underlying spinal muscular atrophy, and roles that SMN gene product plays as a molecular chaperone in mRNA transport and translation; (Va) injury-induced local synthesis of a protein forming a retrograde signaling complex in axons to stimulate regeneration, and (Vb) endogenous and exogenous factors that condition axonal regenerative capacity in PNS and CNS, including injury-induced activation of specific genes governing regeneration.

Emergent complexities revealed in this volume compel a major revision in the traditional conceptual model of the axon’s intrinsic makeup and capacities.

Disclaimer:
Contents of this page are indexed from the Internet. All actions are under your responsability. Email us to report illegal contents or external links and we'll remove them immediately.

Please check the description for download links if any or do a search to find alternative books.

Can't Download?
Please search mirrors if you can't find download links for "Cell Biology of the Axon (Results and Problems in Cell Differentiation)" in "Description" and someone else may update the links. Check the comments when back to find any updates.

Search Mirrors
Maybe some mirror pages will be helpful, search this book at top of this page or click here to find more info.

1. Ebooks list page : 3441
2. Cell Communication in Nervous and Immune System (Results and Problems in Cell Differentiation) by Eckart D. Gundelfinger
3. Cell Biology of the Axon (2009)
4. Embryonic Stem Cell Protocols: Differentiation Models (Methods in Molecular Biology)
5. The Biology of the Pancreatic Beta-Cell (Advances in Molecular and Cell Biology) by: S.L. Howell
6. Atomic Force Microscopy in Cell Biology (Methods in Cell Biology, Volume 68)
7. Methods in Cell Biology, Volume 38: Cell Biological Applications of Confocal Microscopy
8. Methods in Cell Biology, vol.86 - Stem Cell Culture (2008) - RE-POST!
9. Essential Cell Biology: A Practical Approach Volume 2: Cell Function
10. Caspases: Their Role in Cell Death and Cell Survival (Molecular Biology Intelligence Unit)
11. Caspases: Their Role in Cell Death and Cell Survival (Molecular Biology Intelligence Unit)
12. Stem Cell Culture, Volume 86: Methods in Cell Biology
13. Methods in Cell Biology, vol.83 - Cell Mechanics
14. Cell Differentiation Research Developments
15. Cell-Cell Interactions: Methods and Protocols (Methods in Molecular Biology: Volume 341)
16. Neurons: Methods and Applications for the Cell Biologist, (Methods in Cell Biology Volume 71)