Cell Colonization Control by Physical and Chemical Modification of Materials

Description

Cell-material interface plays a key role in the interaction of cells with artificial materials designed for construction of body implants or tissue engineering. Physical and chemical properties of the material surface, such as its polarity, wettability, electrical charge and conductivity, roughness and morphology, rigidity or elasticity as well as the presence of various chemical functional groups, strongly influence the cell adhesion. The latter is mediated by adsorption of cell adhesion-mediating molecules (eg: vitronectin, fibronectin, collagen, laminin, fibrinogen) from the serum of the culture medium or body fluids in appropriate spatial conformation or flexibility enabling the accessibility of specific sites on these molecules (eg: certain amino acid sequences or saccharide-based ligands) by adhesion receptors on the cell membrane (eg: integrins).After binding these ligands, the adhesion receptors are recruited into focal adhesion plaques, where they associate with cascades of various structural and signalling molecules, such as cytoskeletal proteins and kinases. By these cascades, the signal provided by the cell-material interaction is delivered to the cell nucleus. It influences the gene expression, and thus the further behavior of cells, manifested by their viability, synthesis of various molecules, proliferation, differentiation, functioning, immune activation, stress adaptation or cell death.This interdisciplinary review involves: physical modifications of the material surface by plasma discharge, irradiation with ions or ultraviolet light and effects of these modifications on the surface wettability, electrical conductivity and formation of chemical functional groups influencing cell adhesion; deposition of organic or inorganic layers on the material surfaces, especially those nanostructured (eg: nanofibers of fibrin and extracellular matrix molecules, carbon nanoparticles, such as nanodiamonds, fullerenes and nanotubes, nanocomposite metal/C:H layers); functionalisation of the material surface with amino acids and oligopeptidic ligands for cell adhesion receptors (e.g., GRGDSG); and, effect of all these modifications on the extent and strength of adhesion of vascular and bone-derived cells, cell proliferation activity, switch between cell proliferation and differentiation, expression of cell-type specific markers of differentiation and other cell functions.

Enjoy this great book! Brought to you by SMIRK

Disclaimer:
Contents of this page are indexed from the Internet. All actions are under your responsability. Email us to report illegal contents or external links and we'll remove them immediately.

Please check the description for download links if any or do a search to find alternative books.

Can't Download?
Please search mirrors if you can't find download links for "Cell Colonization Control by Physical and Chemical Modification of Materials" in "Description" and someone else may update the links. Check the comments when back to find any updates.

Search Mirrors
Maybe some mirror pages will be helpful, search this book at top of this page or click here to find more info.

1. Ebooks list page : 3368
2. Chemical Modification of Lignocellulosic Materials by David N.-S. Hon
3. Characterization and Chemical Modification of the Silica Surface
4. Wood Modification: Chemical, Thermal and Other Processes
5. Wood Modification: Chemical, Thermal and Other Processes ( Re Upload )
6. Wood Modification: Chemical, Thermal and Other Processes (Wiley Series in Renewable Resource)
7. Wood Modification: Chemical, Thermal and Other Processes (Wiley Series in Renewable Resource)
8. J. Lawrence, Lin Li - Laser Modification of the Wettability Characteristics of Engineering Materials
9. Cambridge University Press "Materials Modification by Electronic Excitation" by Noriaki Itoh, Marshall Stoneham
10. An Introduction to Materials Engineering and Science: For Chemical and Materials Engineers ( Repost)
11. The Chemical of Medical and Dental Materials (Rsc Materials Monographs)
12. Physical-Chemical Treatment of Water
13. Physical Chemistry: Understanding our Chemical World
14. Encyclopedia of Chemical Physics and Physical Chemistry
15. Encyclopedia of Chemical Physics and Physical Chemistry
16. Physical-chemical Treatment of Water and Wastewater