Current Concepts in Normal and Abnormal Puberty,an Issue of Current Problems in Pediatric and Adoles

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Current Concepts in Normal and Abnormal Puberty,an Issue of Current Problems in Pediatric and Adolescent Health Care

Current Concepts in Normal and Abnormal Puberty,
Current Problems in Pediatric and Adolescent Health Care
Volume 37, Issue 2,FEB 2007
Todd D. Nebesio, MD, and Erica A. Eugster, MD

Secular Trends and the Timing of Puberty 50
Variants of Precocious Puberty 51
Premature Thelarche 51
Premature Adrenarche 52
Pathologic Precocious Puberty 52
Central Precocious Puberty-Etiologies 53
Central Precocious Puberty-Treatment 53
Peripheral Precocious Puberty-Etiologies 55
Congenital Adrenal Hyperplasia 55
McCune-Albright Syndrome 55
Familial Male-Limited Precocious Puberty 56
Pseudoprecocious Puberty (Van Wyk-Grumbach
Syndrome)57
Endocrine Disruptors 57
Tumors 58
Other Disorders 58
Prepubertal Gynecomastia 58
Pubic Hair of Infancy 60
Premature Menses 60
Delayed Puberty 60
Constitutional Delay of Growth and Puberty 61
Hypothalamic-Pituitary Dysfunction 61
Primary Hypogonadism 62
Gynecomastia 64
Delayed Puberty-Treatment 65
Conclusion 66

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