Cyclodextrins as new formulation entities and therapeutic agents

Description

Cyclodextrins as new formulation entities and therapeutic agents
Sreevalli Sikharam, Talmage D. Egan and Steven E. Kerna

Cyclodextrins are well-known excipients in thepharmaceutical industry. Their recent application to the anesthetic induction agent propofol as a means of creating a non-lipid formulation may lead to their introduction into anesthesia pharmacology. The development of a novel cyclodextrin as specific reversal agent for the neuromuscular blocker rocuronium (that acts as an in-vivo
scavenging system to bind free rocuronium in the circulation) will also increase the likelihood that cyclodextrins will have a greater clinical presence in
anesthesiology in the future. Cyclodextrin-containing polymers are also finding a role in the delivery of nucleic acids and protein therapeutic agents.

Summary

Recent developments in cyclodextrins as excipients for anesthetics may soon culminate in their introduction into anesthesiology, although more research is necessary to better define their potential.

Keywords
bioavailability, cyclodextrins, formulation, solubility

Curr Opin Anaesthesiol 18:392¨C395. 2005

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