Development and Aging of the Vertebrate Visual System: Special Issue, Neuroembryology and Aging 2006/2007

Description

Introduction
Vision is enormously important as it accounts for 38% of the total sensory input to the brain . Vision can be impaired permanently by a number of conditions. Glaucoma is a severe, sight-threatening disease which is the leading cause of irreversible blindness in the world. Glaucoma is an age-related disease, being more common in the elderly. The prevalence of glaucoma in people aged 40 and over is approximately 2%. As the global population continues to age, it is estimated that the number of glaucoma patients will be increased by 50% by year 2020. People with glaucoma often have elevated intraocular pressure (IOP) of the eye and therefore the major current therapy is to lower the IOP. This is usually achieved initially by drugs but if the hypotensive response is not satisfactory, surgery is then considered. This hypotensive treatment is so far the only proven method to retard glaucomatous damage. However, due to the facts that some patients may eventually develop resistance to these
drugs and these agents do have significant side effects, more potent and selective pharmacologic agents are urgently needed.



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