Fluoropyrimidines in Cancer Therapy (Cancer Drug Discovery and Development)

Description

Fluoropyrimidines in Cancer Therapy (Cancer Drug Discovery and Development)

Publisher: Humana Press
Number Of Pages: 336
Publication Date: 2002-12-02
Sales Rank: 3892759
ISBN / ASIN: 0896039560
EAN: 9780896039568
Binding: Hardcover
Manufacturer: Humana Press
Studio: Humana Press

Leading cancer researchers update and review the mechanisms of action and the therapeutic selectivity and efficacy of 5-FU with and without leucovorin and its prodrugs in the treatment of colorectal cancer. Among the combination agents considered are UFT/LV, 5-FU/EU, capecitabine (Xeloda), S-1, and a variety of thymidylate synthase inhibitors. The authors discuss the potential advantages and disadvantages of these varied drugs and their mode of administration. Based on historical results with these agents when used alone, they also present a rationale for their results when used in combination with other agents.

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