G Protein-Coupled Receptors in Drug Discovery

Description

With more than half of drug targets based on GPCRs, translating into billions in worldwide sales, there is great interest in finding high-resolution structures for recombinantly expressed GPCRs, discovering novel drug interactions, and designing tailor-made, structure-based drug therapies that display improved efficacy and selectivity with lesser side effects. This book describes read.freeduan.com the physiological role of GPCRs and their involvement in various human diseases. Chapters present current approaches in drug discovery that include target selection, establishment of screening, functional assays for GPCRs, and the continuous de-orphanization process of orphan GPCRs. The book also covers recombinant GPCR expression for drug screening and structural biology, different methods to obtain structural information on GPCRs, and the importance of bioinformatics.

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1. Ebooks list page : 2645
2. G Protein-Coupled Receptors in Drug Discovery
3. G Protein-Coupled Receptors in Drug Discovery
4. Methods in Molecular Biology, vol.552 - G Protein-Coupled Receptors in Drug Discovery
5. G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity
6. The G Protein-Coupled Receptors Handbook
7. Orphan G Protein-Coupled Receptors and Novel Neuropeptides
8. Ligand Design for G Protein-coupled Receptors
9. Orphan G Protein-Coupled Receptors and Novel Neuropeptides (2008)
10. G Protein-Coupled Receptors: Structure, Function, and Ligand Screening
11. G Protein-Coupled Receptors: Structure, Function, and Ligand Screening
12. G Protein-coupled Receptors: Molecular Pharmacology By Georges Vauquelin, Bengt von Mentzer
13. Understanding G Protein-coupled Receptors and their Role in the CNS (The Molecular and Cellular Neurobiology Series)
14. Functional Protein Microarrays in Drug Discovery (Drug Discovery Series)
15. Protein Discovery Technologies (Drug Discovery Series)
16. Protein Discovery Technologies (Drug Discovery Series)