Genomics in Regulatory Ecotoxicology: Applications and Challenges

Description

Fueled partially by large, well-publicized efforts such as the Human Genome Project, genomic research is a rapidly growing area in multiple biological disciplines, including toxicology. Much of this potential, however, has been discussed in the literature and at technical meetings only in relatively broad terms, making it difficult to assess exactly how data generated from new genomics technologies might actually impact or benefit the risk assessment process.
Presenting the first in-depth set of recommendations published in the open literature, Genomics in Regulatory Ecotoxicology: Applications and Challenges focuses specifically on how genomics data can be used in regulatory ecotoxicology. The book develops a conceptual framework of how genomics data can most effectively impact current approaches for ecological risk assessments. It also identifies how biomarkers of exposure and effect from both lab and field monitoring studies can be used, including providing a basis for the extrapolation of chemical effects across species.
Aligning environmental science with regulation, the book includes recommendations that guide genomic research such that future developments would have a greater likelihood of contributing to regulatory decision-making. The book outlines the use of techniques such as microarrays to measure changes in thousands of genes or polymerase chain reaction assays or enzyme-linked immunosorbent assays to measure single mRNA products or proteins diagnostic of exposure/effects of chemicals with well-defined modes or mechanisms of action. It explores how data generated from new genomics technologies might impact or benefit the risk assessment process.

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