Growing Bone

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Book Description:
In the new millennium, humans will be traveling to Mars and perhaps beyond with skeletons that respond to microgravity by self-destructing. Meanwhile in Earth's aging populations growing numbers of men and many more women are suffering from crippling bone loss. During the first decade after menopause all women suffer an accelerating loss of bone, which in some of them is severe enough to result in "spontaneous" crushing of vertebrae and fracturing of various bones even by ordinary body movements. This is osteoporosis, which all too often requires prolonged and expensive convalescent care and leads to the further bone loss caused by immobilization, the incapacitation and mental stress of which may even kill the patient. The ominously accelerating microarchitectural deterioration and with it rising microfracturing by the still relatively large muscle pulling of normal activities in aging postmenopausal women is caused by the loss of estrogen. The slower development of osteoporosis in aging men is also partly due to estrogen made in ever smaller amounts in bone cells from the declining level of circulating testosterone. It is needed for bone maintenance just as it is in women. The loss of estrogen triggers a vicious cycle of a disproportionately rising resorptive arm of the coupled resorption -> refilling microcrack-repairing mechanism and a consequently rising fragility and increasing activity-driven microfracturing

Book Info:
Published in 2005
Published by Landes Bioscience
ISBN 1587060256  Size 4.06MB

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