High-Dimensional Data Analysis in Cancer Research

Description

The study of genotype in relation to the risk of specific cancers or other chronic diseases has traditionally relied heavily on family studies. Such studies often involve families having a strong history of the study disease to increase the probability of harboring disease-related genes. A study may involve genotyping family members for a panel of genetic markers and assessing whether one or more markers co-segregate with disease among family members. This approach uses the fact that chromosomal segments are inherited intact, so that markers over some distance from a disease-related gene can be expected to associate with disease risk within families. Following the identification of a “linkage” signal with a genetic marker, some form of fine mapping is needed to close in on disease-related loci.

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