Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy

Description

Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy (Subcellular Biochemistry)

• Publisher: Springer
• Number Of Pages: 380
• Publication Date: 2007-04
• Sales Rank: 3317787
• ISBN / ASIN: 1402056877
• EAN: 9781402056871
• Binding: Hardcover
• Manufacturer: Springer
• Studio: Springer
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Book Description:

In "Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy", a worldwide panel of leading experts discusses the role of inflammation in read.freeduan.com the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. This volume is intended for scientists in medicine, epidemiology, pharmacology, molecular biology, and related fields. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives on the discovery and development of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, and the potential for development of new compounds with better efficacy and safety in the 21^st century. Specfic chapters illuminate the role of inflammatory mechanisms in the pathogenesis of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Experts in cardiovascular medicine explore the "COX-2 controversy" regarding adverse effects of some (not all) selective COX-2 inhibitors on the cardiovasculature. Recent findings suggest that cardiovascular risk associated with some COX-2 inhibitors may not be due to a class effect, but rather depends upon the molecular structure of specific compounds. Important findings are documented in cancer research showing that selective COX-2 inhibitors have powerful antineoplastic effects against major forms of cancer. A special section explores the current evidence supporting the role of COX-2 and inflammation in the development of read.freeduan.com Alzheimer¡¯s disease and other neurodegenerative conditions and the potential benefit of compounds that modulate COX-2 and other inflammatory cytokines. The final section addresses nutritional modulation of inflammation and the chemopreventive value of anti-inflammatory nutraceutical agents.

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