Leukocyte Depletion in Cardiac Surgery and Cardiology

Description

The concept of leukocyte depletion by means of a leukocyte removal filter was introduced by Fleming in 1926 and was also proposed by Wright. During the past decades, leukocyte depletion has become an important tool for the prevention or reduction of the pathogenic effects (posttransfusion syndrome, virus infection/transmission) of blood transfusion. The reduced pathogenicity of leukocyte-depleted blood products significantly reduced the overall cost per patient transfused. Currently, an increasing number of countries recommend or make universal filtration of blood transfusions mandatory. While the filtration
of all blood products is not yet mandatory in the US, the medical community, following the recommendations of the Blood Products Advisory Committee of the FDA, has been advising that all donor blood should be filtered to remove white cells. The American Red Cross has publicly stated its intention to reach this goal by the end of 2001. Routine filtration of all whole blood, red blood cells and platelets has become mandatory in Germany as of October 2001.

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