Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins

Description

Ubiquitin regulates protein transport betweenmembrane compartments by serving as a sorting signal on protein cargo and by controlling the activity of traf-ficking machinery. Monoubiquitin attached to integral plasma membrane proteins or to associated transportmodifiers serves as a regulated signal for internalization into the endocytic pathway. Similarly, monoubiquitin attached to biosynthetic and endocytic membrane proteins is a signal for sorting of cargo into vesicles that bud into the late endosome lumen for delivery into the lysosome. Ubiquitination of trans-acting endocytic proteins is also required for transport, and key endocytic proteins are modified by monoubiquitin. Regulatory enzymes of the ubiquitination machinery, ubiquitin ligases, control the timing and specificity of plasma membrane protein downregulation in such diverse biological processes as cell fate specification and neurotransmission.
Monoubiquitin signals appended by these ligases are recognized by endocytic proteins carrying ubiquitin-binding motifs, including UBA, UEV, UIM, and CUE domains. The UIM proteins epsins and Hrs are excellent candidates for adaptors that link ubiquitinated cargo to the clathrin-based sorting machinery at appropriate regions of the endosomal or plasma membranes. Other ubiquitin-binding proteins also play crucial roles in cargo transport, although in most cases the role of ubiquitin-binding is not defined. Ubiquitin-binding proteins such as epsins, Hrs, and Vps9 are monoubiquitinated, indicating the general nature of ubiquitin regulation in endocytosis and suggesting new models to explain how recognition of monoubiquitin signals may be regulated.

Disclaimer:
Contents of this page are indexed from the Internet. All actions are under your responsability. Email us to report illegal contents or external links and we'll remove them immediately.

Please check the description for download links if any or do a search to find alternative books.

Can't Download?
Please search mirrors if you can't find download links for "Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins" in "Description" and someone else may update the links. Check the comments when back to find any updates.

Search Mirrors
Maybe some mirror pages will be helpful, search this book at top of this page or click here to find more info.

1. Ebooks list page : 3286
2. Ubiquitin and Protein Degradation
3. Ubiquitin and Protein Degradation
4. Protein Degradation, Volume 1: Ubiquitin and the Chemistry of Life
5. Protein Degradation: The Ubiquitin-Proteasome System and Disease
6. Protein Degradation, Volume 2: The Ubiquitin-Proteasome System
7. Protein Degradation, Volume 3: Cell Biology of the Ubiquitin-Proteasome System
8. The Ubiquitin System in Health and Disease (US$99)
9. Ubiquitin and Disease (Molecular Biology Intelligence Unit)
10. Heparin-Binding Proteins
11. Actin-Monomer-Binding Proteins
12. Viral Membrane Proteins
13. Actin-Monomer-Binding Proteins (2006)
14. Membrane Transport
15. Structural Biology of Membrane Proteins (RSC Biomolecular Sciences)
16. Igf-i And Igf Binding Proteins: Basic Research And Clinical Management (Endocrine Development)