Reversible Protein Acetylation (Novartis Foundation Symposia)

Description

A comprehensive review of recent work on chromatin and non-histone proteins, this book arises from the interactions of a multidisciplinary group of scientists involved in the study of acetylation. This area of research opens up new and exciting possibilities for drug design, and so the final chapters in the book examine some of the potential applications in the treatment of various diseases.

Papers from a May 2003 symposium review what has been accomplished in recent years in the field and look into the future of protein acetylation. Contributors in molecular biology, cancer genetics, and pharmacology review the role of histone acetylation and the histone code, discuss enzymes involved in acetylation and their biology, detail recent advances in the acetylation of non-histone proteins, and look at the potential for HDAC inhibitors as anti-cancer agents. They describe research in areas such as the indexing potential of histone lysine methylation, chromatin modifications as clues to the regulation of antigen receptor assembly, dual roles of histone deacetylases in the control of cardiac growth, and p300 and DNA repair. Annotation © 2004 Book News, Inc., Portland, OR

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