Scientific Foundations of Clinical Practice: Part I & II

Description

Scientific Foundations of Clinical Practice: Part II, An Issue of Pediatric Clinics

By Ellis Avner, Robert M. Kliegman,

Publisher: Saunders
Number Of Pages: 240
Publication Date: 2006-10-27
Sales Rank: 3808669
ISBN / ASIN: 1416038973
EAN: 9781416038979
Binding: Hardcover
Manufacturer: Saunders
Studio: Saunders

In the last decade, the delineation of the human genome and the development of high throughput genomics and proteomics have transformed the practice of Pediatrics. The study of normal childhood growth and development, and pediatric diseases now focuses on the delineation of normal and abnormal gene expression, resultant cellular and organ responses, and the modification of such interactions by an increasing number of environmental factors. This is the second of two issues of the Pediatric Clinics of North America will provide an overview of the rapidly developing field of Pediatric Translational Medicine. New knowledge of basic molecular and developmental physiology and pathophysiology is rapidly being "translated" into new diagnostics and therapeutics for the practicing pediatrician. Rapid molecular diagnostics based on the identification of new disease genes, recognition of unique disease phenotypes at the cellular level, and the development of new therapeutic approaches based on pharmacogenomic profiling suggest that "individualized medicine" will soon be a possibility for every child. Combined with similar advances in epidemiology, bioinformatics, and population-based studies, Pediatric Translational Medicine will rapidly move from the laboratory bench to the patient bedside. These issues of the PCNA will be of value to all members of the pediatric health care delivery team, which now includes basic and clinical investigators. Further, it will provide students at all levels with a sense of the excitement which awaits their future development as tomorrow's Physician-Scientists.

Preface
Functional Genomics and Its Implications for Molecular Medicine
Current Methods for the Rapid Diagnosis of Bioterrorism-Related Infectious Agents
Human Artificial Chromosomes: Potential Applications and Clinical Considerations
Inborn Errors of Development: Disruption of Pathways Critical for Normal Development
Transcriptional Regulation of Perinatal Lung Maturation
Renal Cystic Disease: New Insights for the Clinician
Defects in Surfactant Synthesis: Clinical Implications
The Cell Biology of Acute Childhood Respiratory Disease: Therapeutic Implications
Pulmonary Hypertension in Children: The Twenty-First Century
Molecular and Cellular Basis of Congenital Heart Disease
The Molecular Basis of Pediatric Hypertension
Reactive Oxygen Species Cerebral Autoregulation in Health and Disease

http://rapidshare.com/files/38031174/pediatrics_clinics_2006_5.pdf

Scientific Foundations of Clinical Practice: Part I, An Issue of Pediatric Clinics

By Ellis Avner, Robert M. Kliegman,

Publisher: Saunders
Number Of Pages: 240
Publication Date: 2006-08-23
Sales Rank:
ISBN / ASIN: 1416038965
EAN: 9781416038962
Binding: Hardcover
Manufacturer: Saunders
Studio: Saunders

In the last decade, the delineation of the human genome and the development of high throughput genomics and proteomics have transformed the practice of Pediatrics. The study of normal childhood growth and development, and pediatric diseases now focuses on the delineation of normal and abnormal gene expression, resultant cellular and organ responses, and the modification of such interactions by an increasing number of environmental factors. This is the first of two issues of the Pediatric Clinics of North America will provide an overview of the rapidly developing field of Pediatric Translational Medicine. New knowledge of basic molecular and developmental physiology and pathophysiology is rapidly being "translated" into new diagnostics and therapeutics for the practicing pediatrician. Rapid molecular diagnostics based on the identification of new disease genes, recognition of unique disease phenotypes at the cellular level, and the development of new therapeutic approaches based on pharmacogenomic profiling suggest that "individualized medicine" will soon be a possibility for every child. Combined with similar advances in epidemiology, bioinformatics, and population-based studies, Pediatric Translational Medicine will rapidly move from the laboratory bench to the patient bedside. These issues of the PCNA will be of value to all members of the pediatric health care delivery team, which now includes basic and clinical investigators. Further, it will provide students at all levels with a sense of the excitement which awaits their future development as tomorrow's Physician-Scientists.

Preface
Preimplantation Genetic Diagnosis
The Application of Microarray Analysis to Pediatric Diseases
Pharmacogenomics and the Future of Drug Therapy
Gene Therapy: Future or Flop
Pediatric Ethics in the Age of Molecular Medicine
Cellular and Genetic Basis of Primary Immune Deficiencies
Recent Molecular and Cellular Advances in Pediatric Bone Marrow Transplantation
Therapies and Vaccines for Emerging Bacterial Infections: Learning from Methicillin-resistant Staphylococcus aureus
Genetic Aspects of the Etiology and Treatment of Asthma
Inflammatory Bowel Disease¡ªEnvironmental Modification and Genetic Determinants
Application of Genetic Approaches to Ocular Disease
Psychopharmacology: Clinical Implications of Brain Neurochemistry
Obesity and Its Therapy: From Genes to Community Action

http://rapidshare.com/files/38030706/pediatrics_clinics_2006_4.pdf

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