Targeted Interference with Signal Transduction Events (Recent Results in Cancer Research)

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Targeted Interference with Signal Transduction Events (Recent Results in Cancer Research)
Publisher: Springer | ISBN: 3540312080 | edition 2007-07-11 | PDF | 188 pages | 2.74 mb

wo aspects of biological research are major contributors to the progress in the understanding of cancer etiology and the development of new and improved cancer drugs. The sequencing of the human genome provides us with a basic overview of all our genes and gene products, and the insights into signaling pathways allow us to align crucial components of cellular regulation into an ordered functional context. A comparison of the genes in normal and in tumor cells shows that mutations in the DNA of a limited set of genes are responsible for the multiple stages of tumorigenesis and metastasis. Many of the affected genes, including oncogenes, tumor suppressor genes and genome stability genes, can be fitted into pathways. They encode molecules that stimulate tumor cell division or inhibit their death.

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