[request_ebook] The Society of Cells: Cancer and Control of Cell Proliferation (Paperback)

Description

• Author: C Sonnenschein
• Publisher: Springer-Verlag New York Inc
• Publish Date: 1 Nov 1998
• ISBN: 0387915834
• Pages: 154

Book Description
For more than 30 years, the majority of researchers have assumed quiescence to be the default state of all cells and so have provided cells in culture with "growth factors" to allow them to proliferate. During this time, many putative growth factors have been identified and ever more complect mechanisms through which they could interact and stimulate cells have been proposed. However, quiescence as the default state does not make evolutionary sense and many sets of data do not support this hypothesis. In "The Society of Cells", an alternative explanation for these results is proposed by applying the premise that the default state must be proliferation, with division and multiplication being "built in" properties of life.

The authors begin by reviewing the concepts and theories that guide research ont he control of cell proliferation and cancer, and asking the question "what is the nature of the default state of all cells - quiescence or proliferation?" Later chapters concern cancer, where cell proliferate at above normal rates and the usual tissue organization is lost.

Despite decades of work and financial support to explore the somatic mutation theory, we appear no nearer to explainin what causes cancer. This requires researchers to take stock and consider new hypotheses and alternative approaches to the study of cell proliferation, and cancer in particular. "The Society of Cells" is intended to encourage such a re-evaluation.

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