Understanding DNA: The Molecule and How it Works. Third Edition

Description

• Author: Chris R. Calladine, Horace Drew, Ben Luisi, Andrew Travers

The functional properties of any molecule are directly related to, and affected by, its structure. This is especially true for DNA, the molecular that carries the code for all life on earth.



The third edition of Understanding DNA has been entirely revised and updated, and expanded to cover new advances in our understanding. It explains, step by step, how DNA forms specific structures, the nature of these structures and how they fundamentally affect the biological processes of transcription and replication.



Written in a clear, concise and lively fashion, Understanding DNA is essential reading for all molecular biology, biochemistry and genetics students, to newcomers to the field from other areas such as chemistry or physics, and even for seasoned researchers, who really want to understand DNA.



* Describes the basic units of DNA and how these form the double helix, and the various types of DNA double helix

* Outlines the methods used to study DNA structure

* Contains over 130 illustrations, some in full color, as well as exercises and further readings to stimulate student comprehension



Review

Praise for previous editions:

"Stylish...beautifully crafted, with a logical step-by-step approach to the subject. A book from which the advanced undergraduate will benefit and which will also generate a refreshing perspective for experts"

-NATURE



"Understanding DNA is a great book that will surely prove to be a valuable teaching tool."

-THE BIOCHEMIST



"A systematic and comprehensive analysis of the structure of DNA from a wonderfully fresh perspective."

-TRENDS IN GENETICS



Preface

Chapter 1 An Introduction to Molecular Biology for Non-Scientists

Chapter 2 Why a Helix?

Chapter 3 Different Kinds of Double Helix

Chapter 4 Twisting and Curving

Chapter 5 Curving in Three Dimensions

Chapter 6 DNA Supercoiling

Chapter 7 The Assembly of DNA into Chromosomes

Chapter 8 Specific DNA-Protein Interactions

Chapter 9 Methods Used to Study the Structure of DNA

Chapter 10 DNA in Disease, Diagnostics, and Medicine

Chapter 11 Cytosine Methylation and DNA Epigenetics Postscript

Appendix 1: Notes on the Derivation of Some Technical Terms

Appendix 2: The Chemical Theory of Base-stacking Interactions in DNA

Appendix 3: How to modify Gene Expression Using Anti-sense Oligonucleotides, Ribozymes or Small Interfering-RNA

Answers to Selected Exercises

Index

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